Kidneys are silent superheroes. They filter blood, balance electrolytes, and remove toxins and extra water from the body. Basically, they ensure the body stays healthy by filtering out what it doesn’t need. But when kidneys begin to fail, the warning signs are often silent.
Learn the warning signs, play our interactive memory game to explore simple prevention steps, and discover how kidney health and sustainability go hand in hand this World Kidney Day 2026.
Chronic kidney disease (CKD) often develops silently, and symptoms progressively worsen as it advances. But there are early clues to watch for. Recognizing these signs can help detect CKD sooner to slow or delay its progression. Watch for fatigue, poor mobility, bone or joint pain, and drowsiness.
What our doctors wish everyone knew about chronic kidney disease:
Early detection of kidney disease is vital as it often develops silently, without obvious symptoms. Identifying signs early allows for timely treatment, helping prevent serious complications and protecting your long-term health.
Recognizing the risks and symptoms can help you and your loved ones act sooner and protect long-term health.
Here are the biggest risk factors:
Match the pairs to unlock the eight golden rules to reduce the risk of developing chronic kidney disease (CKD) and related conditions, such as diabetes, high blood pressure, and obesity.14-17 Each match reveals a healthy action you can put into practice.
Publication date: March 2026
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2 Kovesdy CP. Epidemiology of chronic kidney disease: an update 2022. Kidney Int Suppl (2011). 2022;12(1):7-11. doi:10.1016/j.kisu.2021.11.003
3 GBD Chronic Kidney Disease Collaboration. Global, regional, and national burden of chronic kidney disease, 1990-2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet. 2020;395(10225):709-733. doi:10.1016/S0140-6736(20)30045-3
4 Hill NR, Fatoba ST, Oke JL, et al. Global Prevalence of Chronic Kidney Disease - A Systematic Review and Meta-Analysis. PLoS One. 2016;11(7):e0158765. Published 2016 Jul 6. doi:10.1371/journal.pone.0158765
5 Centers for Disease Control and Prevention. Risk Factors for Chronic Kidney Disease. Chronic Kidney Disease Initiative. Published 2024. https://www.cdc.gov/kidney-disease/risk-factors/index.html Kim K CJLCNHAALJ. Epidemiology of Diabetic Kidney Disease among US Veterans. Diabetes Metab Syndr Obes. 2024;17:1585-1596. Kim K CJLCNHAALJ. Epidemiology of Diabetic Kidney Disease among US Veterans. Diabetes Metab Syndr Obes. 2024;17:1585-1596.
6 Francis A, Harhay MN, Ong ACM, et al. Chronic kidney disease and the global public health agenda: an international consensus. Nat Rev Nephrol. 2024;20(7):473-485. doi:10.1038/s41581- 024-00820-6
7 American Kidney Fund. Risk factors for kidney disease. Updated 2024. Accessed December 2, 2024. https://www.kidneyfund.org/all-about-kidneys/risk- factors
8 Centers for Disease Control and Prevention (CDC). Risk factors for chronic kidney disease. Updated April 3, 2023. Accessed December 2, 2024. https://www.cdc.gov/kidney-disease/risk-factors/index.html
9 Kidney Disease: Improving Global Outcomes (KDIGO) CKD Work Group. KDIGO 2024 Clinical Practice Guideline for the Evaluation and Management of Chronic Kidney Disease. Kidney Int. 2024;105(4S): S117–S314.
10 A National Institute of Diabetes and Digestive and Kidney Diseases. Prevention of chronic kidney disease (CKD). National Institute of Diabetes and Digestive and Kidney Diseases. Updated February 2021. Accessed December 2, 2024. https://www.niddk.nih.gov/health-information/kidney-disease/chronic-kidney-disease-ckd/prevention
11 B Kelly JT, Su G, Zhang L, et al. Modifiable Lifestyle Factors for Primary Prevention of CKD: A Systematic Review and Meta-Analysis. J Am Soc Nephrol. 2021;32(1):239-253. doi:10.1681/ASN.2020030384
12 World Kidney Day. About Kidney Health: What is Chronic Kidney Disease? Diagnosis. Accessed December 30, 2024. https://www.worldkidneyday.org/about-kidney-health/
13 Bowe B, Artimovich E, Xie Y, et al. The global and national burden of chronic kidney disease attributable to ambient fine particulate matter air pollution: a modelling study. BMJ Global Health 2020;5:e002063. doi:10.1136/bmjgh-2019-002063
14 Liu J, Varghese BM, Hansen A, et al. Projection of high temperature-related burden of kidney disease in Australia under different climate change, population and adaptation scenarios: population-based study. Lancet Reg Health West Pac. 2023;41:100916. Published 2023 Oct doi:10.1016/j.lanwpc.2023.100916 - Quantifies current and future kidney-disease burden in high temperate climates
15 Liu J, Varghese BM, Hansen A, et al. Hot weather as a risk factor for kidney disease outcomes: A systematic review and meta-analysis of epidemiological evidence. Sci Total Environ. 2021;801:149806. doi:10.1016/j.scitotenv.2021.149806 - Includes a pooled meta-analysis of 32 studies that found a 1 degree C increase in temperature was linked to an 11% increase in kidney failure (CI 1.09-1.13)
16 Lee J, Oh S, Byon JY, et al. Long-term exposure to high perceived temperature and risk of mortality among patients with chronic kidney disease. Heliyon. 2024;10(3):e25222. Published 2024 Jan 24. doi:10.1016/j.heliyon.2024.e25222 - Found an increased all-cause mortality risk in CKD with chronic heat exposure (HR 1.29; CI 1.25-1.33; p < 0.05)
17 kidney.org/treatment/askthedoctor. Accessed 22 January 2024
18 The Complex Relationship Between Kidney Health and Our Environment, The Complex Relationship Between Kidney Health and Our Environment | Docwire News
19 ASN Statement on Climate Change: https://www.asn-online.org/policy/webdocs/22.4.22StatementOnClimateChange.pdf
20 Chronic Kidney Disease in Outdoor Workers in Latin America
21 Cardio-renal-metabolic diseases and climate adaptation strategies
22 Journal of Renal Nutrition (Bergling K, Wang LC, Shivakumar O, Nandorine Ban A, Moore LW, Ginsberg N, Kooman J, et al. From bytes to bites: application of large language models to enhance nutritional recommendations. Clin Kidney J. 2025 Mar 17;18(4):sfaf082. doi: 10.1093/ckj/sfaf082. PMID: 40226366; PMCID: PMC11992566.)